349 results
Is there a significant difference in Anterior/Posterior stability between MRK, LCS and NexGen total knee prosthesis 1 year post-op?
After a runic phase of 2 weeks, we will study whether cotreatment of oral E hallii once daily given for 2 weeks on top of stable metformin dosage improves (postprandial) glycemic control in DM2 subjects compared to once daily glycerol placebo with…
We hypothesize that ingestion of potato protein increases muscle protein synthesis rates at rest as well as during recovery from exercise in young healthy males. We hypothesize that the muscle protein synthetic response to the ingestion of potato…
1) There will be an effect of anodal stimulation to the left STG with reduced response bias on the signal detection task 2) This effect is specific for speech signal detection.
the present study investigates whether Circadian adjusted LED-based (biodynamic) lighting improve cognitive functions, circadian rhytm, behavioral problems (apathy and agitation), Quality of life and mood (depression) in patiënts with moderate- to…
Evaluation of the safety and tolerability of AP3066 in healthy males
The primary aim of this project is to further elucidate the (neural) mechanisms of ketamine, which may underlie its (rapid) antidepressant response.
We hypothesise that zoned high compression shorts significantly decrease groin pain in football players without reducing performance.
adults. We hypothesize that test product NL-01, which is an extract from food crops enriched for IMPP-1, a compound that supports innate immune function, increases resistance to acute respiratory tract infections (ARTI) in the winter season
Sodium phenylbutyrate administration in patients with T2D would improve whole body insulin sensitivity.
The hypothesis formulation for the primary outcome parameter is: - H0: The effect of using product A is unequal to the effect of using product B with respect to serum P AUC0-360 [mmol/L*min] in subjects with elevated gastric pH. - H1: The effect of…
To assess whether whey protein supplementation during the days before and after muscle-damaging eccentric exercise improves recovery of muscle strength, compared to placebo?Secondary objective(s) are: To assess whether whey protein supplementation…
Primary:-To evaluate the efficacy of KEVZARA (sarilumab) in patients with polymyalgia rheumatica (PMR) as assessed by the proportion of subjects with sustained remission for sarilumab with a shorter corticosteroid (CS) tapering regimen as compared…
The primary aim of the study is to compare the effects of protein versus placebo supplementation on 24 hour post-race delayed onset muscle soreness after strenuous endurance exercise performance among endurance runners.The secondary aim of the study…
This study will be performed in 124 healthy male volunteers. The study will be performed in 2 parts, Part A and Part B.Part A will be performed in 64 healthy male volunteers divided over 8 groups of 8 volunteers each.Part B will be performed in 60…
Primary objective: To compare the effect of semaglutide s.c. 2.4 mg once-weekly versus semaglutide placebo as an adjunct to reduced-calorie diet and increased physical activity in subjects with overweight or obesity who have reached target dose of…
To demonstrate whether hydrochlorothiazide or metformin can diminish aquaresis in patients with ADPKD who are treated with tolvaptan as measured by 24-hour urine volume.
The primary objective of this study is to show equivalence of the total pathological complete response rate (tpCR) in patients treated withHD201 plus chemotherapy to that in patients treated with Herceptin® plus chemotherapy. tpCR will be assessed…
The primary objective of this study is:* To investigate whether a two-weeks intervention with cerebellar anodal tDCS could improve ataxia severity in SCA3 patients compared to sham stimulation.Secondary objectives of this study are:* To investigate…
Primary Objective:The primary objective of this study is to provide confirmatory data on the beneficial effect of 2.0 g/kg of Octagam 10% given every 4 weeks compared with placebo in subjects with active DM based on the percentage of responders at…