453 results
We propose to conduct a study in patients with mild to moderate AD where a cholinergic challenge is given in a placebo-controlled, cross-over fashion, prior to onset of treatment with a CEI. Patients will be followed over a period of 6 months to…
The aim of this prospective study is 1) to evaluate the diagnostic efficacy of DBE in comparison to MRE as surveillance technique of the small-bowel in PJS patients, 2) to analyze patient burden and quality of life with DBE and MRE, and 3) to…
A fundamental question in the current research proposal concerns how changes in cognitive and social-emotional behavior are related to functional and anatomical brain development. The current proposal has the objective to (a) understand the neural…
The main objective is to describe the interactions between physical sensory stimulations and high-level prior assumptions that give rise to visual perception. In two secondary objectives, we will advance novel model-based neuroimaging data-analysis…
The main objective of this study is to determine the added value of NIR fluorescence imaging in patients with pancreatic cancer undergoing SL and to identify predictors for patients that may benefit from SL.
To determine the effect of a structured diagnostic-therapeutic strategy to detect and treat previously unrecognized or unestablished heart failure in primary care as compared to care as usual.
Primary Objective:To assess the ability of BR55 to identify area(s) of VEGFR2 expression in human prostate by ultrasound molecular imaging on the basis of a visual score in comparison with histopathology analysis (location based on expression of…
This study aims at the questions about anterograde amnesia. How often does it occur in patients being treated with bilateral ECT for a depressive disorder, how does anterograde amnesia develop during the treatment course and how does it subside…
To improve our insight in chronic pain and to develop methodologies to treat chronic pain.
The aim of the current study is to identify couplings of muscle activation patterns (muscle synergies) in reaching movements in stroke patients. Insight in the motor control of stroke patients can contribute to improve the disabled arm functioning…
How does motor fatigue influence the cognitive functioning of patients with MS and how does this interaction compare to that in healthy controls?
Objective: Primarily, the objective of this study is to assess the role of serotonergic and dopaminergic polymorphisms in fear conditioning. Secondary, we will investigate additional cannabinergic and corticotropinergic polymorphisms in fear-…
This project examines their relative contribution using pupil dilatation and concentration cortisol and alpha amylase in saliva as objective measures of mental effort and questionnaires. Young and elderly normally hearing and hearing impaired…
To optimize the management of non-chronic shoulder pain in primary care by the introduction of ultrasound as a diagnostic triage tool. The following research questions will be addressed:1. What are the effects of diagnostic ultrasound and its…
Overall aim of the study is to investigate which decision-making models for patient participation are used in practice in end-of-life decision-making and how appropriate are these models for different patient groups.Secondary Objective(s): 1. In…
To study the relation between face processing and activation in cortical pathways in adults with Autism Spectrum Disorder.
We aim to document the brain anatomy and functioning and development of children and adolescents of different ages who suffer from Prader-Willi syndrome in order to gain insight into the possible relation between the observed behavior and the brain…
Primary Objective: To study the arginine-NO metabolism during fracture healing and dysfunctional fracture healingSecondary Objective(s): To investigate if differences or decreased arginine and NO concentrations in bone healing form a prognostic…
The purpose of this pilot study is twofold: - evaluation of the tumour movement and regression during and short after long course pre-operative therapy for locally advanced rectal cancer in order to develop an integrated or sequential dose…
To investigate whether high resolution multi-site epicardial mapping of the atria in patients with structural heart disease undergoing cardiac surgery can identify patients at risk for developing early post-operative atrial fibrillation. The…