285 results
Primary Objective: • To investigate whether or not persistent complaints and poor outcome after mTBI be explained by an interaction between physiological and psychological factors. In other words, the aim is to investigate whether a more optimal…
10 years ago we selected an unique cohort of 154 patients with acute ACL injuries, who were prospectively characterized over the first two years post-injury. A single follow-up measure within this established cohort is proposed, to those that gave…
The goal of this research project comprises two important components that are intricately related:1) To define the pathophysiological state of the peripheral motor pathway in patients with SMA and to determine the contribution of the constituting…
(I) To compare patient friendliness in adult psoriasis patients between two non-invasive cytokine detection methods: TAP and TAPE. (II) To assess the correlation in cytokine detection by TAP and TAPE stratum corneum sampling in psoriasis patients.
To assess T cell activation in patients with extremely high Lp(a) levels versus controls with low Lp(a)
Primary Objective: To identify the variability in the circulation of the number of patrolling monocytes and their expression of CX3CR1 obtained from adult ZZ-AATD patients compared to spouse controls.Secondary Objective(s): (1) To identify if low…
The quality and quantity of the innate immune response to bacteria should be tightly regulated leading to resolution of infection while minimizing damage to host tissue. We hypothesize that this regulation depends on gestational age at delivery and…
Using epigenetic, transcriptional, metabolomic and proteomic approaches in cardiac and skeletal muscle tissue, we want to reveal distinct biological pathways affected in ACM, DCM and PLN r14del cardiomyopathy.
To explore cardiovascular remodelling with subsequent altered cardiac function (assessed as strain rate) in extremely premature neonates (born <30 weeks and/or birth weight < 1000 gram) with FGR.
Primary objective:1. To identify the components in human milk (e.g. nutrients, oligosaccharides, fatty acids and (pathogen specific) immunoglobulins) that have a protective effect against respiratory tract infections during the first year of life.…
Objective: To determine the incidence of asymptomatic oral and corneal HSV-1 shedding.
To study the effects of in vitro culture conditions, such as different culture media or oxygen tension, on omic layers (i.e. genome, epigenome and transcriptome) of preimplantation human embryos and to relate this to chromosoom instability (CIN).
1) To study the effects of antibody removal by immunoadsorption on the immune phenotype over time in patients with B-cell related autoimmune diseases such as MG, AAV, anti-GBM disease, cryoglobulinemic vasculitis and other refractory antibody-…
We aim to find immune defects and related genetic variants in patients who have recovered from secondary HLH
This study aims to isolate and culture myogenic stem cells called mesoangioblasts from the muscle biopsies to explore if genetic correction of LAMA2 mutations using CRISPR-Cas9 can be achieved and subsequently assess the effect in vitro, as a first…
Our main objective is to dissect the genomic determinants of treatment-related adverse events after lymphoma, specifically cardiovascular disease and second malignant neoplasms. As such, we will assess the association of genetic and epigenetic…
This is the first study to combine both objective and subjective daily measures (EMA and actigraphy) to assess fluctuations in suicidal ideation, in real time and in natural settings. The aims of the study are (1) to examine how momentary risk and…
The primary objective of this study is to generate reference values for NFMS parameters as well as for 2D-STE parameters during the second trimester, 16 until 28 weeks gestational age. The secondary objective is to investigate the diagnostic…
This study has been transitioned to CTIS with ID 2024-517636-22-00 check the CTIS register for the current data. The main objective of the present study is to investigate the association between in vivo regional synaptic loss ([18F]SynVesT-1 PET),…
To quantify the role of different abnormal loading conditions on atrial and ventricular electropathology in paediatric patients with CHD.