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Investigating normal variability in brain volumes and cognition in a healthy population.

The objective of the current study is to obtain normative data of healthy individuals on brain measures, cognition and blood markers. In addition, we acquire information on childhood trauma, metabolic and immunological parameters in a cohort of…

Cognitive behavioral therapy versus a combination of pain neurophysiology education and cognitive behavioral therapy in patients with chornic musculoskeletal pain

Our research question is: *What is the additional value of pain neurophysiology education when it precedes cognitive behavioral therapy on the physical and psychological functioning of patients with chronic musculoskeletal pain?

The LIPMAT study: Liposomal prednisolone to improve hemodialysis fistula maturation

To demonstrate whether liposomal prednisolone is effective in promoting AVF maturation after surgical creation of a radiocephalic AVF.

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of ABT-494 for the Induction of Symptomatic and Endoscopic Remission in Subjects with Moderately to Severely Active Crohn's Disease who have Inadequately Responded to or are Intolerant to Immunomodulators or Anti-TNF Therapy

The objectives of this study are to determine the efficacy and safety of multiple doses of ABT-494 versus placebo and to assess the pharmacokinetics (PK) of ABT-494 following oral administration in subjects with moderately to severely active Crohn…

Coordination of trunk, head and arm movements during functional tasks, in healthy children and children with Duchenne muscular dystrophy, spinal muscular atrophy and cerebral palsy.

First objective: gain insight in the coordination of trunk, head and arm during functional tasks in healthy children and compare this with the coordination in children with DMD, SMA and CP. Second objective: investigate if newly developed supportive…

A Phase III, double-blind, randomized, placebo-controlled multi-centre, study to assess the efficacy and safety of AZD9291 versus Placebo, in patients with Epidermal Growth Factor Receptor Mutation Positive stage IB-IIIA non-small cell lung carcinoma, following complete tumour resection with or without adjuvant chemotherapy (ADAURA)

To assess the efficacy of AZD9291 compared to placebo as measured by disease free survival (DFS)Protocol v1.0, 4Jun2015, p30

The role of the intestinal microbiome in enteric and systemic vaccine immune responses

Primary Objective: to investigate the role of the gut microbiota in RVV immune response Secondary Objectives: To investigate the role of the gut microbiota in tetanus and pneumococcal vaccine immune responses

Economic evaluation of treatment modalities for position dependent obstructive sleep apnea patients

To evaluate the effect and cost-utility of positional therapy, comparing the SPT and MRA versus CPAP in patients with moderate positional obstructive sleep apnea.

Dutch randomized multicenter trial COmparing twO PalliativE RAdiaTION schemes for incurable head and neck cancer (COOPERATION)

to investigate the oncologic outcomes, toxicity and QoL of two commonly used palliative radiation schemes in the Netherlands

The Role of Conditioning for Pharmacotherapeutic Treatments in Rheumatoid Arthritis.

This study aims to enhance pharmacotherapeutic effects in patients with recent-onset RA by means of conditioning (via a variable reinforcement schedule).

A Phase I Open-Label, Safety, Pharmacokinetic, and Preliminary Efficacy Study of CriPec® docetaxel in Patients with Solid Tumours.

Circulating CriPec docetaxel nanoparticles are designed to be in a higher degree than the original compound (docetaxel) to be trapped in tumor tissue due to the enhanced penetration and retention (EPR) effect. Subsequent release of docetaxel from…

INFLAMMATION IN ATHEROSCLEROTIC PLAQUES: ENHANCED BY MAJOR SURGERY OR SEPSIS?

With this study we will evaluate the following hypothesis: Does acute systemic inflammation induces plaque instability and could it be repsonsible for the elevated risk of cardiovascular events. Eventually this study can contribute to the knowledge…

A Phase III, randomised, double blind, placebo-controlled, parallel group, efficacy, safety and tolerability trial of once daily, oral doses of empagliflozin as adjunctive to insulin therapy over 26 weeks in patients with Type 1 Diabetes Mellitus (EASE-3)

The objective of this study is to assess the efficacy, safety, tolerability and pharmacokinetics (PK) of once daily oral doses of empagliflozin 2,5mg, 10mg and 25mg in patients with Type 1 diabetes mellitus (T1DM) as adjunctive to insulin therapy.…

Effect of Computer-Controlled Cooling on Surgical Aspects after a Displaced Intra-Articular Calcaneal Fracture (Cool-DIACF); A Multicenter Randomized Controlled Trial

Primary Objective:To examine the effect of pre-operative cooling versus pressure bandage on the time to surgery in adult patients who sustained a displaced intra-articular calcaneal fracture (DIACF) that will be treated operatively using an extended…

Pilot study: Fosfomycin levels in prostate tissue after oral and iv administration

To measure intraprostatic concentrations and serum levels of fosfomycine after a single oral or intravenous dose prior to TURP. This is done to achieve more insight in whether fosfomycin is a suitable antibiotic to use as profylaxis or treatment of…

Evaluation of the optical effects of healthy and diseased ocular anterior segment structures on quality of vision

To document mean and range of straylight values in patients with anterior segment disorders possibly under several visual angles

A prospective study to a blended ACT e-health training in curative treated breastcancer patients with distress: results and patient reports.

Aim of this study is getting a first indication from the effects described above (decrease distress, increase wellbeing). We will investigate if the effects found in general population even can be found in breastcancer patients and if there is a…

Cost-effectiveness and cost-utility of at-home infrared temperature monitoring in reducing the incidence of foot ulcer recurrence in patients with diabetes.

To assess the cost-effectiveness and cost-utility of at-home foot temperature monitoring to reduce incidence of foot ulcer recurrence in patients with diabetes. Main research questions:1. What is the cost-effectiveness of enhanced therapy in…

ENdometrial cancer SURvivors' follow-up carE (ENSURE): Less is more? Randomized controlled trial to evaluate patient satisfaction and cost-effectiveness of a reduced follow-up schedule

The aim of this study is to compare a reduced follow-up schedule of 4 visits among low-risk, early-stage endometrial cancer survivors, with the schedule according to the current Dutch guideline that includes 10 to 13 visits, on:Primary outcomes:1.…

Cold and hot water immersion as a strategy to promote post-exercise recovery in healthy young men.

To assess the effect of a 2 week resistance exercise training program combined with CWI on muscle protein synthesis and the reponse to the ingestion of a single bolus of protein and carbohydrate after post-exercise CWI or HWI on muscle protein…