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Trauma-focused exposure therapy for posttraumatic stress disorder in patients with eating disorders

The current study is an initial evaluation of the feasibility and effects of exposure therapy in those suffering from ED and comorbid PTSD.

A multicenter, randomized, active-controlled, double-blind, double-dummy, parallel group clinical trial, investigating the efficacy, safety, and tolerability of continuous subcutaneous ND0612 infusion in comparison to oral IR-LD/CD in subjects with Parkinson*s disease experiencing motor fluctuations (BouNDless)

Primary ObjectiveThe primary objective of the study is to determine the effect of ND0612 on daily *ON* time without troublesome dyskinesia (defined as the sum of "ON" time without dyskinesia and *ON* time with non-troublesome dyskinesia)…

Comparison of different transfusion strategies for red blood cell transfusion dependent MDS and MPN patients - a cross-over study with remote patient monitoring

Compare the effect of three different RBC transfusion strategies* (Standard of care (SoC), SoC+1 and SoC+2**) on heart rate in a population of chronically transfused patients (with on average at least 1 RBC transfusion each 8 weeks as personal…

High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

This study has been transitioned to CTIS with ID 2024-514917-36-00 check the CTIS register for the current data. PRIMARY OBJECTIVES*Rx-induction: Comparison of the 3 year EFS rate of 2 induction regimens, GPOH and RAPID COJEC, in patients with high-…

[18F]fluor-PEG-folate PET/CT imaging in Giant Cell Arteritis.

Primary Objective: to evaluate arterial [18F]fluor-PEG-folate uptake on PET/CT in patients with active, large vessel GCA; and in the same patients after 9 months of standard treatment.Secondary objectives are:- Assessment of the relationship between…

A Phase III Double-Blind, Randomised, Placebo-Controlled Study Assessing the Efficacy and Safety of Capivasertib + Abiraterone Versus Placebo + Abiraterone as Treatment for Patients with De Novo Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) Characterised by PTEN deficiency (CAPItello-281)

This study has been transitioned to CTIS with ID 2023-504998-20-00 check the CTIS register for the current data. - To compare the effect of capivasertib + abiraterone relative to placebo + abiraterone by assessment of radiographic progression-free…

Effectiveness of drainage of the kidney by percutaneous nephrostomy catheter placement versus retrograde double J catheter placement in patients with symptoms of obstructive kidney disease caused by uroithiasis.

The primary objective is to assess whether a PCN is non-inferior to double J catheter regarding time to clinical recovery in patients with obstructive kidney disease resulting from urolithiasis.As the secondary objective we would like to investigate…

A multicenter, randomized, double-blind, parallel-group, placebo-controlled study to evaluate the efficacy and safety of finerenone on morbidity and mortality in participants with heart failure (NYHA II-IV) and left ventricular ejection fraction >= 40% (LVEF >= 40%).

To demonstrate the superiority of finerenone to placebo in reducing the rate of the composite CV endpoint.To determine superiority of finerenone to placebo for each secondary endpointTo assess the safety and tolerability of finerenone

Azole-echinocandin combination therapy for invasive aspergillosis. A randomized pragmatic superiority trial (IA-DUET)

Primary objective 1. Evaluate if the survival in patients with a triazole susceptible IA can be improved when the initial therapy consists of triazole and echinocandin combination therapy instead of triazole monotherapy. (This objective is captured…

AmbuLatory Pediatric Asthma CAre: The effect of online monitoring and communication on the quality and quantity of pediatric asthma care.

Evaluate the effect of pediatric asthma eHealth care on the healthcare utilization, asthma outcomes and quality of life.

TGF-β And PDL-1 inhibition with Bintrafusp alfa in Esophageal Squamous Cell carcinoma combined with chemoradiation TheRapY (TAPESTRY)

This study has been transitioned to CTIS with ID 2023-503312-32-00 check the CTIS register for the current data. Possibly, outcomes of treatment of irresectable squamous cell carcinoma of the esophagus can be improved by adding bintrafusp alfa to…

CO-HEALTHY - COllaboration between parents and childcare to promote a HEALTHY lifestyle in young children.

The project primarily aims to examine the effects of a preschool-based intervention on the ECEC teacher-parent partnership regarding eating, physical (in)activity and sleeping behaviours in young children.

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Evaluating the Efficacy and Safety of Bimekizumab in Study Participants With Moderate to Severe Hidradenitis Suppurativa

The purpose of this study is to find out how safe and effective a new drug called bimekizumab is for long-term use in treating hidradenitis suppurativa. Bimekizumab (hereafter referred to as *the study drug*) has been approved by the health…

Tofacitinib in the treatment of chronic, recurrent and/or antibiotic refractory pouchitis: a multi-omics approach

To assess efficacy and safety of tofacitinib in the treatment of chronic, recurrent and/or antibiotic refractory pouchitis.

A PHASE II, MULTICENTRE, OPEN-LABEL STUDY OF CABOZANTINIB AS 2ND LINE TREATMENT IN SUBJECTS WITH UNRESECTABLE, LOCALLY ADVANCED OR METASTATIC RENAL CELL CARCINOMA WITH A CLEAR-CELL COMPONENT WHO PROGRESSED AFTER 1ST LINE TREATMENT WITH CHECKPOINT INHIBITORS

The overall objective of this study is to evaluate the efficacy and safety of cabozantinib as 2nd line treatment in subjects with unresectable, locally advanced or metastatic renal cell carcinoma (RCC) with a clear-cell component, who progressed…

Treatment of Hemorrhoids: Rubber band ligation Or Sclerotherapy

We want to compare the effectiveness of sclerotherapy and rubberband ligation when it comes to symptoms. We will secondarily consider patient satisfaction, complications and recurrences. We hypothesize that both treatments are equally effective.

Phase I/Ib, open-label, multiple ascending dose, first-in-human study, to investigate the safety, pharmacokinetics, pharmacodynamics and preliminary efficacy of INT-1B3 in patients with advanced solid tumors

Primary Objectives:Phase 1/ Dose escalation:• To determine the safety and tolerability of INT-1B3, administered as single agent by 120-min i.v. infusion• To identify the Recommended Phase 2 Dose (RP2D) of INT-1B3 Phase 1b/ Dose expansion:• To…

HELIOS-B: A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Vutrisiran in Patients with Transthyretin Amyloidosis with Cardiomyopathy (ATTR Amyloidosis with Cardiomyopathy)

This study has been transitioned to CTIS with ID 2024-518318-25-00 check the CTIS register for the current data. Primary: • To evaluate the efficacy of vutrisiran compared to placebo on reducing all-cause mortality and cardiovascular (CV)-related…

Prolonged Dual Hypothermic Oxygenated Machine Preservation of Human Liver Grafts: A Feasibility Trial

To study the safety and efficacy of prolonged (>2 hours) end-ischemic DHOPE, by assessing the occurrence of (serious) adverse events during machine perfusion and within 30 days after liver transplantation.

A Randomized, Open label, Non-inferiority trial on the efficacy of Lacosamide versus Duloxetine in Patients with Chemotherapy-induced Polyneuropathy - a strategy trial

This study has been transitioned to CTIS with ID 2024-511008-17-00 check the CTIS register for the current data. To assess whether lacosamide is as efficient in the treatment of chemotherapy-induced neuropathic pain as duloxetine