142 resultaten
Interindividual variation in antihypertensive drug response can be predicted through lifestyle, demographics and plasma drug levels.
We hypothesize that TRH effectively antagonize opioid-induced respiratory depression
Patient decision aids (PDA) for prostate cancer have been developed to help patients make a deliberative choice for a treatment option for their disease. Despite proven benefits of PDAs, structural implementation falls short of expectations. To…
The nephrotoxicity caused by cisplatin is of great concern both in that it is dose-limiting and can be detrimental to the patient. Much work has been done to reduce or prevent this damage to renal cells, however to date the best approach has reduced…
Golimumab 100 mg every 1,5 month has similar trough levels to golimumab 50 mg every month; golimumab 100 mg every 2 months has a similar AUC to golimumab 50 mg every month.
A 4-month WFPD H0: has no effect on the levels of serum uric acid in patients with gout, hyperuricemia and abdominal obesity in comparison with usual care. H1: results in decreased levels of serum uric acid in patients with gout, hyperuricemia and…
Budesonide does not alter the exposure of cabazitaxel in castrate resistant prostate cancer patients.
To demonstrate wether there is difference in tissue oxygen tension and extravascular lung water while patients are being resuscitated with cristalloids or colloids combined with cristalloids.
Consumption of slowly digestible starch is implicated with a decreased risk for the development of obesity, insulin resistance and Type 2 diabetes (T2DM). Underlying mechanisms of this beneficial effect are not yet elucidated. The objective of this…
It is hypothesised that inhaled mannitol 400 mg b.d. will lead to a significant improvement in the absolute change in percentage of predicted FEV1 from baseline following eight-weeks of trial treatment compared to treatment with inhaled placebo b.d…
With a recently developed Ara h6 ELISA we would like to show the effect of exercise on circulating Ara h6 after peanut consumption
After absorption tamoxifen is metabolized by CYP3A4 and CYP2D6 in several (active) metabolites of which endoxifen is the most important.(11) Tamoxifen, like many anti-cancer drugs, relies on phase II metabolism before they can be excreted from the…
Cholesterol lowering by low fat diet and lovastatin will also reduce very long chain fatty acids in patients with X-ALD.
We hypothesize that bi-daily 5ml NaCl 7% nebulizations improve respiratory symptoms and quality of life in PCD patients compared to 5ml NaCl 0,9% nebulizations.
The administered protein mix is related to a faster postprandial amino acid bioavailability compared to a single protein as measured by the t½ of the iAUC.
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Cannabinoid receptor (CB1) agonists, like marinol, lower the rate of TLESRs and can be useful in the treatment of gastroesophageal reflux disease (GERD).
Thiopurine induced hepatotoxicity is related with an enhanced state of oxidative stress and may ameliorate after N-acetylcysteine supplementation.
This is an exploratory pilot study without specific hypotheses.