46 resultaten
Extension of SAD PK/PD Model, confirmation of SAD PD effects
Systemic eosinophilic inflammation in airway disease (asthma/COPD/asthma-COPD-overlap-syndrome (ACOS)) is associated with small airway inflammation manifesting in dynamic hyperinflation and specific symptoms, which can be reduced by systemic anti-…
H1: Exposure to a mode tailored website as compared to exposure to a standardized website will have a positive effect on distress before the consultation (H1a), communication characteristics during consultation (H1b), distress directly after the…
1. Tapentadol produces effective pain relief in low back pain patients 2. Tapentadol treatment improves/enlarges CPM in patients with CPM defects 3. Tapentadol treatment improves/reduces temporal summation 4. Tapentadol is most efficacious in…
We postulate that faecal microbiota transplantation (FMT) from obese donors in patients with cancer can improve satiety (appetite) and subsequently nutritional status. Secondly, FMT might restore the gut barrier function and hence reduce systemic…
It is hypothesized that the outcome of the outcome parameters will be superior for the test product compared to the control product: No difference for the test product compared to the control product is anticipated for the outcome parameter…
1. Tapentadol produces effective pain relief 2. Tapentadol treatment improves/enlarges CPM resonses 3. Tapentadol treatment improves/reduces temporal summation responses 4. Tapentadol treatment improves/reduces offset analgesia responses 5.…
Treatment of fear of falling in hip fracture patients in GR, using the FIT-HIP intervention, will lead to reduction of fear of falling and therefore to an improvement of mobility function (gait and balance), in comparison to patients with fear of…
this study hypotheses that EEG does not predict future seizures. If correct abandoning routinely EEG will lead to a reduction in health costs and patient/family burden. Furthermore, neurocognitive development will be investigated two years after…
To study if a Mediterranean diet (MD) followed by lean donor fecal microbiota transplantation (FMT) has synergistic superior beneficial effects on peripheral insulin sensitivity and (small) intestinal microbiota composition as compared to…
The use of a GDFT protocol during liver surgery instead of the widely used LCVP regimen has no influence on blood loss.
A single exercise bout with a minimum duration of 10 minutes and a moderate to vigorous intensity level has small but positive effects on cognitive performance in children. These acute effects on cognitive performance are thought to be mediated by…
Patients treated with ziprasidone reveal fewer negative symptoms on the PANSS negative symptoms sub-scale and/or better scores on the CGI therapeutic effects sub-scale (CGI-TE) than patients treated with low-dose conventional antipsychotics (5 mg/…
In this double-blind randomized placebo-controlled trial, we hypothesize to observe a reduced incidence of antibiotic associated diarrhae (AAD) in inpatients with a spinal cord injury (SCI) during the intake of probiotics, in comparison to a placebo…
Primaire doelstelling: Beoordelen of ixekizumab in Week 12 superieur is ten opzichte van placebo in de behandeling van patiënten met matige-tot-ernstige genitale psoriasisBelangrijke secundaire doelstelling:Beoordelen of ixekizumab in Week 12…
Aantonen dat orale antistollingsmiddelen met het NOAC edoxaban beter is dan de huidige therapie (trombocytenaggregatieremmers of geen behandeling afhankelijk van het cardiovasculaire risico) ter voorkoming van een beroerte, systemische embolie of…
Primaire doelstelling- Het bepalen van het voordeel van behandeling met enzalutamide + ADT in vergelijking met placebo + ADT, vastgesteld door een centrale beoordeling van de radiografische progressievrije overleving (radiographic progression-free…
Primary Objective: Laten zien dat L-theanine positieve angstverlagende effecten heeft in gezonde participanten. Met de huidige experimentele opzet verwachten we de volgende effecten van L-theanine ten opzichte van placebo:• Verminderde Fear-…