49 results
Primary Objective: (diagnostic)• Does MRI detect structural changes of haemophilic arthropathy in knees and ankles undetected by the Pettersson score and HJHS? (Research question 1 a & b)Secondary Objective(s): (prognostic)• Can MRI predict…
The assessment of the duration of the cellular immunity to Bordetella pertussis after an extra ACV booster and the relationship between the memory B- cells and antibody responses. The methods used in the study are:B- and T- cell memory responses and…
To characterise the number, phenotype and functionality of regulatory T cells and cytokines produced in the peripheral blood of children diagnosed with asthma.
To assess whether Th17 cells play a central role in COPD, CF and pneumonia pathogenesis
Primary objective:What is the effect of a 12 weeks physical exercise program on the exercise induced inflammatory response in patients with cystic fibrosis?Secundary objectives:- What are the differences in pre-training basal immune values of…
The objective of this study is to investigate the effects of replicated and theoretically interesting autism risk genes on brain anatomy in ASD. We will use psychiatric genetics and gene expression patterns to predict neuroimaging findings in ASD.
Aims: 1. To optimize the diagnosis of M. pneumoniae infections by discriminating between colonization and symptomatic infection using quantitative PCR. 2. To study the role of host factors (age, and bacterial and viral co-infection) on infection by…
1 To determine the phenotype and biological characteristics of mesenchymal stem cells derived from pediatric MDS patients as determined by flow cytometric analysis, cell culture and differentiation abilities analyzed by subtype of MDS compared to de…
Primary objective: to determine the effect of Mindful MirrorExposure in the treatment of eating disordered patients.
The research strives for a large group of homogeneous AID patients, so that a powerful association study can be performed to detect genetic risk factors. These factors can be shared by several AIZ, or be specific is for a single AID. The aim of this…
Determining the prevalence of testicular microlithiasis in Down syndrome.
Primary objectives:(1) To describe the incidence of EV and HPeV infections in Dutch children(2) To determine the major symptoms of EV/HPeV infections in children(3) To evaluate the epidemiology and symptoms of the different subtypes of EV and HPeV(4…
(1) to determine the psychiatric status (ADHD and ODD/CD) for the second time in participants from ADHD and control families about 5 years after the first assessment. The participants will be between 10 and 23 years of age now; (2) to determine the…
Objective of the study: The main objective of this study is to investigate the influence of different genetic mechanisms (risk genes, CNVs and gene expression profiles) in ASD and to study the relation between the genetic heterogeneity and specific…
This hypothesis will be challenged in five objectives:1. To check the factorial validity of two cognitive styles - weak central coherence; poor cognitive shifting - in patients with MR and ASS.2. To assess the specificity of the association between…
- To determine physical fitness in children with a congenital heart disease (ventricular septum defect, atrium septum defect, tetralogy of Fallot, transposition of large arteries and patients after a (modified) Fontan-operation) and to compare…
The overall aim of the study is to enrich the database of the Dutch IMAGE samples with (1) structural magnetic resonance imaging (sMRI) and functional MRI (fMRI) data; (2) follow-up data of clinical status (ADHD symptoms and relevant comorbidities)…
The objectives of this study are:1) assess the differences in pain sensitivity between children with and without chronic pain2) collecting normative data for pain sensitivity in children aged 8-123) investigate the relationship between parental…
First, to develop a diagnostic method for non-infectious uveitis in childhood. Second, to analyze iris and ciliary body tissues of children with uveitis on the presents of inflammatory infiltrate. The results of this study will contribute in the…
Objectives: In this study we investigate possible correlations between cognitive impairment as well as response to AED treatment in children with FLE and abnormalities in brain micro-structure, function and neuronal connectivity. Therefore, we apply…