391 resultaten
1. Patients, starting with PFME before radical prostatectomy, have a shorter duration and a lower degree of post-operative urinary incontinence than patients who start with PFME after surgery; 2. Patients, performing pre-operative PFME and PFME…
The present study aims at testing whether the positive effect of rinsing 3 weeks with a combination of chloorhexidine and sodiumperoxyborate will last up to 9 months and possibly up to 12 months. This concept placed in a future prospective could…
New perioperative care program will improve return to (work)activities, quality of life and quality of recovery in patients undergoing gynaecological surgical procedures, compared to usual given care.
The difference between both interventions is the absence of intestinal decontamination during SOD and the standard use of cephalosporins for all patients during SDD. It has been hypothesized that eradication of the intestinal Gram negative bacterial…
1. We hypothesize that methylphenidate will decrease the activation in the dopaminergic nuclei and will increase the activation in the dopaminergic projection regions during rest and during reward processing during the gambling task; 2. We…
It is hypothesized that treatment with B cell directed therapy in the pre-clinical phase of RA will decrease the development of arthritis.
Statin therapy increases DDAVP stimulated release of von Willebrand factor and factor VIII in patients with mild Hemophilia A and type 1 von Willebrand disease.
Fibronectin testing as a triage for women with threatened preterm labor is a cost effective strategy.
To evaluate the usefulness of the VascuLuminator for venous cannulation in children.
Goal is to develop an algorithm for determination of the timing and magnitude of the peak growth velocity in the individual patient with adolescent idiopathic scoliosis.
The pathophysiology of premature atherosclerosis is poorly understood. Patients often display few risk factors, but the clinical manifestations are evident. If atherosclerosis is expressed at a very young age, it is likely that besides the classical…
This study aims to test the efficiency and cost-effectiveness of a brief collaborative care intervention, in long-term users (>9months) of antidepressants in the general practice. This intervention will contain a patient-tailored treatment…
Acute challenges with cocaine and cannabis will induce two opposing dopaminergic states in the brain. Cocaine will stimulate dopamine release leading to hyperdopaminergia whereas cannabis will reduce central dopamine levels resulting in…
1. Viscosupplementation therapy for patients with osteoarthritis of the knee is cost-effective for the dutch health care system; 2. Viscosupplementation therapy for patients with osteoarthritis of the knee has a clinical relevant effect competed to…
Recent data showed for the first time that IgE-ACPA antibodies have a direct biological immune response in mast cells of IgE-ACPA+ RA patients. Subsequently, mast cell targeting agents, such as anti-IgE therapy have rationale for application in RA…
1. DCS enhances the speed and size of effect of exposure therapy in panic disorder and OCD; 2. This DCS enhancement is independent of the nature of the anxiety provoking situations (OCD-related versus panic-related); 3. There is no difference in…
The null hypothesis for this study is that endovascular treatment for acute ischemic stroke with onset of less than six hours in patients with a symptomatic intracranial proximal arterial occlusion, leads to a similar distribution of functional…
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Children of parents with a mental illness or substance use disorder have high elevated risks to develop (mental and behavioural) problems themselves. Hypothesis is that the online Kopstoring intervention will be effective and cost-effective…
The skin lesions of HS patients will significantly more improve after treatment with Multiplex laser combined with methyl aminolevulinate than after treatment with the only the multiplex laser.