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Randomized maintenance therapy with Azacitidine (Vidaza) in older patients (>= 60 years of age) with acute myeloid leukemia (AML) and refractory anemia with excess of blasts (RAEB, RAEB-t).

The hypothesis to be tested is that the outcome in arm B is better than in arm A.

Multislice computed tomography coronary angiography in patients with stable and unstable angina: a multicenter study.

Is diagnostic non-invasive coronary angiography with MS-CT a cost-effective alternative to diagnostic invasive coronary angiography in the management of patients with stable and unstable angina pectoris, referred for evaluation of the presence of…

Comparison of different doses of levobupivacain for caudal block in children undergoing hypospadia repair.

N/A

The effect of Pyridostigmine on patients with CRPS-1.

Pyridostigmine will activate the parasympathetic cholinergic anti-inflammatory pathway and therefore reduce inflammatory signs and symptoms in patients with complex regional pain syndrome.

Diffusion of computer tailored behavior change programs through the Health Monitor system.

By using a proactive approach (prompts) compared to a reactive approach CT (computer tailored) program use will be increased by 20 %.

Leiden-Alloimmunization-Likelihood (LAL)trial.

The use of by filtration-leukocyte reduced blood transfusions in patients undergoing cardiac surgery, will result in lower alloimmunization frequencies compared to using buffy-coat depleted blood transfusions. This has previously been shown in…

The Sevoflurane study, understanding the effects of Sevoflurane to improve safety and outcome of cardiac surgery.

This study will test the hypothesis that Sevoflurane attenuates oxidative damage, complement, enothelial, thrombocyt and neutrophil activation and inflammation to human ischemia reperfusion injury of the myocardium.

Preventing Preterm birth with Progesterone: Costs and effects of screening healthy women with a singleton pregnancy for a short cervical length.

Progesterone treatment for women with a short cervical length is effective in reducing the risk of preterm delivery.

Randomized phase III study of Rituximab with intensified CHOP chemotherapy vs. Rituximab with High-Dose Sequential Therapy and Autologous Stem Cell Transplantation in Adult Patients (18-65 yrs) with Stage II-IV High-intermediate or High Risk DLBCL.

The hypothesis to be tested is that the outcome in arm B is better than in arm A.

Effects of long-term treatment with modafinil on relapse and impulse control in alcohol dependence.

It is expected that modafinil improves cognitive functioning in abstinent alcohol dependent patients, increases time to first relapse and reduces relapse rates and relapse severity. In addition, it is expected that participants with different…

Comparison of the effectiveness of a behavioural graded activity program and manual therapy in patients with sub-acute neck pain.

N/A

A pilot randomized controlled trial comparing the effect of minimal invasive technique vs. standard (dermo)fasciectomy surgery in patients with primairy Dupuytren's contracture on convalescence, contracture correction and recurrence rate.

The percutaneous and lipofilling technique has a shorter convalescence.

Randomized controlled trial of psychiatric consultation embedded in continuing education to company physicians for employees with sick leave absence through psychiatric disorders.

In a randomized controlled study comparing psychiatric consultation with care as usual by the company physician, patients will improve in the intervention group in terms of duration of sick leave, general functioning and quality of life.

A Double-Blind, Double-Dummy, Randomized, Placebo-Controlled, 3-Period, Crossover Study to Investigate the Effects of Ethanol and L-000830982 on Essential Tremor.

1. The effect of a single oral dose of L-000830982 versus oral placebo and an intravenous infusion of ethanol versus placebo on tremor over a 8-hour period in men and women with essential tremor will be estimated; 2. The sensitivity and specificity…

Treatment of Complex Regional Pain Syndome type 1: a randomised, double-blind, placebo-controlled study with S(+)-ketamine.

S(+)-ketamine reduces pain in patients with Complex Regional Pain Syndome type 1 having symptoms shorter than 6 months and longer than 3 years.

Tamoxifen and Exemestane Adjuvant Multicenter trial.

Alternative hypothesis is that the HR is 1.28 for relapse free survival for the first 2¾ years.

The stories we live by, a life-review method for people of 55 years and over with depressive and anxiety symptoms.

Our main hypothesis is that the life-review intervention leads to a significant reduction of depressive and anxiety symptoms, and in current major depression, and a significant improvement in quality of life and positive mental health, compared to…

The clinical effects of leukocyte removal filters, cellsavers and their combination on blood transfusion and organ damage during cardiac surgery.

We hypothesize that the application of a leukocyte depletion filter for surgical wound blood will reduce organ damage and coagulation disorders through removal of activated leukocytes and other particles. We expect that the efficacy of a cell saver…

Innovative approaches for cocaine pharmacotherapy using fMRI: the case of varenicline.

Varenicline reduces craving to cocaine and/or impulsivity in human cocaine users.

Randomized phase II/III study of Risedronate in combination with Docetaxel versus Docetaxel alone in patients with hormone refractory prostate cancer.

Clinical studies with mitoxantrone and clodronate showed a better pain reduction in patients with prostate cancer. Both in vitro and animal studies have shown that paclitaxel and biphosphonates act synergistically and prevent formation and…