849 resultaten
We hypothesize that by using different imaging techniques, we can give a good characterization of the bone marrow microenvironment in advanced-stage myelofibrosis, before and during treatment with ruxolitinib.
H1: the exercise intervention is effective in reducing (work-related) fatigue H2: the exercise intervention is effective in improving (work-related) self-efficacy, sleep quality, work ability, cognitive functioning, and aerobic fitness.
1. The point of the skin with best possible transcutaneous nerve stimulation correlates with the point of the skin most superficial to the nerves stimulated within a range of 3 mm; 2. Ultrasound will reveal a significant number of sensitive…
Children aged 4 to 6 years in the intervention group who have received the GigaGaaf! intervention have a different oral health than children aged 4 to 6 years from the control group who have received care as usual. Parents of the children aged 4 to…
We hypothesize that a treatment algorithm that is based on a simple validated measure of health status (CCQ) improves quality of life (as measured on a separate scale) and other classical COPD outcome measurement parameters such as exacerbation…
Public health authorities have recognized lack of hand hygiene (HH) as one of the important causes of preventable mortality and morbidity at population level. Both at national (UK, USA, Dutch VMS) and international levels (WHO) poor HH has been…
The hypothesis to be tested that the outcome in arm B is better than in arm A.
1. The treatment group will increase their Theory of Mind skills in comparison to the waitlist control group; 2. The conceptual skills will improve at a higher rate than the practical skills.
Because of the high cardiovascular risk profile and functional disabilities of obese long-standing type 2 diabetes patients, therapeutic exercise programs have hardly been evaluated in this subpopulation. The current research proposal aims to…
Informed consent procedures and information provision differs between different transplantation centers and transplantation professionals in The Netherlands. Donor knowledge and satisfaction may be influenced by the manner of information provision…
The objective of the study is to identify factors associated with anterior knee pain after primary total knee replacement.
The percutaneous and lipofilling technique has a shorter convalescence.
There seems to be a biphasic process of bone mineral density (BMD) changes in osetoarthritis (OA). An increased bone mineral density (BMD) and a specific distribution of BMD in the cortical of the subchondral plates and below in the trabecular bone…
To study the accuracy of the PISAPED perfusion scan criteria compared with CT scanning in patients aged < or = 50 years with suspected pulmonary embolism, a likley or high clinical probability and/or an abnormal D-dimer.
We propose that kinase activity profiling may be a potential clinical diagnostic tool to predict for tumor response to targeted therapy with tyrosine kinase inhibitors (TKI's).
We hypothesise endo/epicardial substrate homogenization in a first approach to be superior to endocardial substrate homogenization alone, in terms of recurrence on follow-up.
The pharmacotherapeutic treatment of patients with cancer is generally associated with multiple side-effects. The cause of the side-effects is usually due to the toxicity of the drugs themselves. In addition, drug interactions can intensify side-…
Based on its general pro-hemostatic potential, prothrombin complex concentrate may be effective in (completely or partially) reversing the anticoagulant effect of the new antithrombotic agents Dabigatran and Rivaroxaban.
The hypotheses of this study are that parents at increased risk of parenting problems who receive the intervention Solid Parenting (“Stevig Ouderschap”) during the first 18 months after childbirth, will enhance their social support network and…
MR Elastography can be used as a non-invasive tool to diagnose, stage and monitor liver fibrosis. MR Elastography has a better accuracy than FibroScan for the assessment of intermediate fibrosis stages.