527 resultaten
In the RIO study programme, the efficacy of rimonabant was examined. The next step is to assess the use of rimonabant, its safety and effectiveness in daily practice. In daily practice people also have other diseases, may use other medication and…
Several open-label pilot studies have shown a promising effect of intrapyloric botulinum toxin injection on symptoms in severe gastroparesis. However, data from randomized, double-blind, placebo-controlled studies are not yet available. We intend to…
We hypothesize that a treatment algorithm that is based on a simple validated measure of health status (CCQ) improves quality of life (as measured on a separate scale) and other classical COPD outcome measurement parameters such as exacerbation…
1: Long term use of fluoxetine causes the excitability of the primary motor area of the brain to change 2: Long term administration of fluoxetine causes the muscle activation patterns to change
DBS in the nucleus accumbens can lead to long-term improvement of obsessive-compulsive symptoms and funtioning, without unacceptable side-effects.
Prolonged antibiotic treatment of patients diagnosed with presumed PLD (as endorsed by the international ILADS guidelines) leads to better patient outcome than short-term treatment as endorsed by the Dutch CBO guidelines.
1. In the first intervention group, the % of subjects who meet the national physical activity guideline will significantly increase; 2. In the second intervention group the % of subjects who meet the national physical activity guideline will…
The TENLEP Trials proposal builds on the findings of the INFIR Cohort Study and the recommendations of the NLR-funded international Workshop on Neuropathology in Leprosy in the Netherlands in 2007. At this workshop, several key research questions…
Dietary intervention using the food for special medical purposes in question to address specific nutrient deficiencies has a positive effect on cognitive performance in patients with early Alzheimer’s Disease.
Based on its general pro-hemostatic potential, prothrombin complex concentrate may be effective in (completely or partially) reversing the anticoagulant effect of the new antithrombotic agents Dabigatran and Rivaroxaban.
Improvement of the intestinal microflora of children consuming a fibre-enriched versus a standard paediatric tube feed.
In the present study we will investigate the pharmacokinetic profile of three doses of sublingual testosterone, and measure subjective and physiological measures of sexual functioning in healty premenopausal women. The lowest effective dose of…
RhDNase can liquefy mucus in children with an atelectasis during mechanical ventilation, resulting in improved mucociliary clearance, less mucus retention and less airways obstruction, thereby enhancing the rate of resolution of an atelectasis.…
To determine whether doubling the dose of corticosteroid injections in the treatment of arthritis in knee joints is more effective, both in number of responding patients and in duration of response (pain relief).
rhDNase improves lung function in children with persistent asthma who have persistent obstructive pulmonary function; Treatment of mucus impaction is an interesting alternative approach to treat peripheral airflow limitation in asthmatic patients.…
Based on systematic reviews concerning effective treatments in children with migraine a medical treatment (propanolol) as well as a non-medical treatment (relaxation therapy) appear to be effective compared to no treatment or placebo. however their…
Aetiology of late-onset depressive spectrum disorders may be different from the aetiology of early-onset depression. Concordant with the supposed aetiology of dementia, it has been postulated that chronic low grade immune activation plays a role in…
Our hypothesis is that peroperative fluid restriction will lead to a significant reduction of solid phase gastric emptying time ¨C measured by radionuclide scintigraphy-, and a reduction in its related postoperative complications.
A positive effect of the investigational product on the intestinal microbiota of healthy Asian toddlers is expected.
1. Imipramine and Venlafaxine are comparable in efficacy in inpatients with a major depression; 2. Imipramine and Venlafaxine are comparable in tolerability; 3. Patients with a Venlafaxine plasma level < 195 µg/L show comparable…